Blocked: wine start/unix
The file '/media/My Passport/Softwares/Setup.exe' is not marked asexecutable. If this was downloaded or copied from an untrusted source, it may be dangerous to run. For more details, read about the executable bit.
Then you are at the right place. Just do the following:
1. Copy the .exe file to your system (home/desktop: Just to make it sure the file is not on a removable media.)
2. Right click on the .exe file. Click Properties.
3. Click Permissions tab.
4. Check the option: Execute: Allow executing file as program.
5. Close and run it.
You would able be execute it without any errors this time with Wine.